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| Jim Carrey | Carl |
| Zooey Deschanel | Allison |
| Bradley Cooper | Peter |
| John Michael Higgins | Nick |
| Rhys Darby | Norm |
| Danny Masterson | Rooney |
| Fionnula Flanagan | Tillie |
| Terence Stamp | Terrence |
| Sasha Alexander | Lucy |
| Molly Sims | Stephanie |
| Brent Briscoe | Homeless Guy |
| Rocky Carroll | Wes |
| John Cothran | Tweed |
| Spencer Garrett | Multack |
| Patrick Labyorteaux | Marv |
| Jamie Denbo | Marv's wife |
Carl Allen is stuck in a rut with his negative ways. Then he goes to a self-help seminar and learns to unleash the power of yes. Living in the affirmative leads him to all sorts of amazing and transforming experiences; he gets a job promotion, and even finds a new romance. But Carl finds that too much of anything, even positive thinking, is not necessarily a good thing.
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