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| Molly Shannon | Peggy |
| Laura Dern | Bret |
| Regina King | Layla |
| Tom McCarthy | Pier |
| Peter Sarsgaard | Newt |
| John C. Reilly | Al |
| Josh Pais | Robin |
| Liza Weil | Trishelle |
| Steve Berg | Steve |
| Chuck Duffy | Jeff |
| Susan Mackin | Susan |
| Christy Moore | Candy |
| Inara George | Holly |
| Dale Godboldo | Don |
After her beloved beagle dies unexpectedly, an office worker named Peggy looks for ways to fill the void in her life. Bringing in treats for her co-workers and fussing over other people's children fails to work, and when an ill-advised love affair with a gun fanatic dies on the vine, she ``goes to the dogs'' in more ways than one.
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