| Vin Diesel | Xander "XXX" Cage |
| Asia Argento | Yelena |
| Marton Csokas | Yorgi |
| Samuel L. Jackson | Agent Augustus Gibbons |
| Danny Trejo | El Jefe |
| Michael Roof | Toby Lee Shavers |
| Tom Everett | Senator Dick Hotchkiss |
| Richy Muller | Milan Sova |
| Werner Daehn | Kirill |
| Eve | J.J. |
| Leila Arcieri | Jordan King |
| William Hope | Agent Roger Donnan |
| Tony Hawk | Caddy Driver |
| Brian Deegan | Extreme Guy |
| Mike Vallely | Skater |
| Rob Wells | Hillside Video Shooter |
| Rick Thorne | Himself |
| Cary Hart | Caddy Passenger |
| Colin McKay | Van Driver |
| Jason Ellis | Van Video Shooter |
| Martin Barta | Male Opera Singer (Don Giovanni) |
| Martina Bauerova | Female Opera Singer (Zerlina) |
A government agent recruits an athlete to stop an anarchist from using biological and chemical weapons.
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