| Ice Cube | Darius Stone |
| Willem Dafoe | George Deckert |
| Scott Speedman | Agent Kyle Steele |
| Peter Strauss | Sanford |
| Samuel L. Jackson | Agent Augustus Gibbons |
| Xzibit | Zeke |
| Michael Roof | Agent Toby Lee Shavers |
| Sunny Mabrey | Charlie |
| Nona Gaye | Lola |
| John G. Connolly | Lt. ``Bama'' Cobb |
| Matt Gerald | Liebo |
| Ned Schmidtke | Gen. Jack Pettibone |
| Barry Sigismondi | Bull |
In Washington, D.C., the new XXX agent must eliminate a threat to the president from within the U.S. government.
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