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| Nicolas Cage | Sgt. John McLoughlin |
| Michael Peña | Officer Will Jimino |
| Maggie Gyllenhaal | Allison Jimeno |
| Maria Bello | Donna McLoughlin |
| Stephen Dorff | Scott Strauss |
| Jay Hernandez | Dominick Pezzulo |
| Michael Shannon | Dave Karnes |
| Nicholas Turturro | Officer Colovito |
| William Mapother | Thomas |
| Jude Ciccolella | Inspector Fields |
| Donna Murphy | Judy Jonas |
| Brad William Henke | Jerry |
| Patti D'Arbanville | Lynne |
| Kurt Caceres | Billings |
| Nick Damici | Kazmatis |
| Lucia Brawley | Karen |
| Danny Nucci | Officer Giraldi |
| Gary Stretch | Jimmy McGuinness |
Two Port Authority officers, Sgt. John McLoughlin and Officer Will Jimeno, become trapped in the rubble of the World Trade Center after going in to help people escape from the buildings during the terrorist attacks of Sept. 11, 2001.
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