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| Katharine Hepburn | Tess Harding |
| Spencer Tracy | Sam Craig |
| Fay Bainter | Ellen Whitcomb |
| Reginald Owen | Clayton |
| Minor Watson | William J. Harding |
| William Bendix | ''Pinkie'' Peters |
| Gladys Blake | Flo Peters |
| Dan Tobin | Gerald Howe |
| Roscoe Karns | Phil Whittaker |
| William Tannen | Ellis |
| Ludwig Stossel | Dr. Lubbeck |
| Sara Haden | Matron |
| Edith Evanson | Alma |
| Henry Roquemore | Marcus P. Calverton |
| Cyril Ring | Mr. Harding's Chauffeur (uncredited) |
| Ben Lessy | Punchy (uncredited) |
| John Berkes | Pal (uncredited) |
| Duke York | Football Player (uncredited) |
| Winifred Harris | Chairlady (uncredited) |
| Joe Yule | Building Superintendent (uncredited) |
Tess Harding is a progressively-minded political journalist. Sam Craig is a sports writer with very traditional values. The only thing the two have in common is that they both work for the same New York City newspaper. Despite an initial and mutual dislike, the two eventually fall in love and get married. When Tess wins the Woman of the Year award, traditional gender roles become flipped and their relationship suffers as a result.
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