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| Adam Arkin | Steve Hersh |
| Robert Costanzo | Johnny DiMartino |
| Beverly D'Angelo | Theresa Carpenter |
| Elle Macpherson | Samantha Mastandrea |
| Amy Madigan | Hannah DiMartino |
| Laura San Giacomo | Joanne Hersh |
| David Strathairn | Armand Minetti |
| Jon Tenney | Dorian Mastandrea |
| Lauren Tom | Yolanda Chin |
| Carmine Costanzo | Nino DiMartino |
| Tom La Grua | Head Mob Guy |
| Garry Marshall | Frank Minetti |
| Michael McKean | Dr. Maxwell Hersh |
| Ashley Peldon | Marissa DiMartino |
| Jon Polito | Rudy Ptak |
| Armando Pucci | Dr. Puccini |
| Andrew Shaifer | Trent Rabinowitz |
| Heather Stephens | Babette |
| Bill Murray | Maurice Melnick |
| Martin Scorsese | Himself |
Four Los Angeles pals, all second bananas, compete for a choice role in a Martin Scorsese gangland film.
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