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| Adam Arkin | Steve Hersh |
| Robert Costanzo | Johnny DiMartino |
| Beverly D'Angelo | Theresa Carpenter |
| Elle Macpherson | Samantha Mastandrea |
| Amy Madigan | Hannah DiMartino |
| Laura San Giacomo | Joanne Hersh |
| David Strathairn | Armand Minetti |
| Jon Tenney | Dorian Mastandrea |
| Lauren Tom | Yolanda Chin |
| Carmine Costanzo | Nino DiMartino |
| Tom La Grua | Head Mob Guy |
| Garry Marshall | Frank Minetti |
| Michael McKean | Dr. Maxwell Hersh |
| Ashley Peldon | Marissa DiMartino |
| Jon Polito | Rudy Ptak |
| Armando Pucci | Dr. Puccini |
| Andrew Shaifer | Trent Rabinowitz |
| Heather Stephens | Babette |
| Bill Murray | Maurice Melnick |
| Martin Scorsese | Himself |
Casting agents for an upcoming Martin Scorsese movie suggest that actor Johnny DiMartino try out for a part, and he thinks it might be his big break. When his fellow actor buddies, Steve Hersh, Armand Minetti and Dorian Mastandrea, hear about Johnny's opportunity, they marvel at his good fortune. Soon, as their bemused significant others look on, the four pals are trying to outmaneuver one another and win a spot in the film's cast.
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