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| Tim Allen | Doug Madsen |
| John Travolta | Woody Stevens |
| Martin Lawrence | Bobby Davis |
| William H. Macy | Dudley Frank |
| Ray Liotta | Jack |
| Kevin Durand | Red |
| Jill Hennessy | Kelly Madsen |
| Marisa Tomei | Maggie |
| Tichina Arnold | Karen Davis |
| M. C. Gainey | Murdock |
| Dominic Janes | Billy Madsen |
| Stephen Tobolowsky | Charley |
| Jason Sklar | Earl Dooble |
| Randy Sklar | Buck Dooble |
| Drew Sidora | Haley Davis |
| Cymfenee | Claire Davis |
| Margaret Travolta | Dana |
| Michael Hitchcock | Kent |
| Drew Pinsky | |
| Kyle Gass | Kyle |
| Peter Fonda | Damien Blade |
Tired of their humdrum lives, some middle-aged friends decide to temporarily ditch their responsibilities and take a motorcycle trip. The freedom of the open road holds many surprises for the group, including an encounter with the Del Fuegos, a hardcore gang, who take a dim view of the novice bikers.
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