|Billy Crystal||Harry Burns|
|Meg Ryan||Sally Albright|
|Lisa Jane Persky||Alice|
|Michelle Nicastro||Amanda Reese|
|Harley Jane Kozak||Helen|
In 1977, college graduates Harry Burns and Sally Albright share a contentious car ride from Chicago to New York, during which they argue about whether men and women can ever truly be strictly platonic friends. Ten years later, Harry and Sally meet again at a bookstore, and in the company of their respective best friends, Jess and Marie, attempt to stay friends without sex becoming an issue between them.