| Larry David | Boris Yellnikoff |
| Evan Rachel Wood | Melody |
| Patricia Clarkson | Marietta |
| Ed Begley Jr. | John |
| Michael McKean | Joe |
| Henry Cavill | Randy James |
| John Gallagher Jr. | Perry |
| Jessica Hecht | Helena |
| Carolyn McCormick | Jessica |
| Christopher Evan Welch | Howard |
After a failed suicide attempt, brilliant New York misanthrope Boris Yellnikoff forsakes his posh upper-class existence for meager accommodations in Chinatown. He meets his exact opposite in Melody, a pageant queen from the Deep South who's long on sweetness but short on smarts. Surprisingly, Boris and Melody marry, but the sparks really fly when Melody's born-again Christian mother arrives and finds liberation instead of damnation.