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| Ryan Reynolds | Monty |
| Anna Faris | Serena |
| Justin Long | Dean |
| David Koechner | Dan |
| Luis Guzmán | Raddimus |
| Chi McBride | Bishop |
| John Francis Daley | Mitch |
| Kaitlin Doubleday | Amy |
| Robert Patrick Benedict | Calvin |
| Alanna Ubach | Naomi |
| Vanessa Lengies | Natasha |
| Max Kasch | T-Dog |
| Andy Milonakis | Nick |
| Dane Cook | Floyd |
| Jordan Ladd | Danielle |
| Emmanuelle Chriqui | Tyla |
| Wendie Malick | Monty's Mom |
| Monica Monica | Dean's Mom |
| Travis Resor | Chett |
| Clay Chamberlain | Video Host |
| Skyler Stone | Cook #1 |
| Melissa Morgan | Bitchy Lady |
| Don Brady | Old Man |
A womanizing waiter, his former girlfriend and his housemate ponder their lives while working at a chain restaurant.
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