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| Hugh Jackman | Gabriel Van Helsing |
| Kate Beckinsale | Anna Valerious |
| Richard Roxburgh | Count Vladislaus Dracula |
| David Wenham | Carl |
| Shuler Hensley | Frankenstein's Monster |
| Elena Anaya | Aleera |
| Will Kemp | Velkan |
| Kevin J. O'Connor | Igor |
| Alun Armstrong | Cardinal Jinette |
| Silvia Colloca | Verona |
| Josie Maran | Marishka |
| Tom Fisher | Top Hat |
| Samuel West | Dr. Victor Frankenstein |
| Robbie Coltrane | Mr. Hyde |
Famed monster slayer Gabriel Van Helsing is dispatched to Transylvania to assist the last of the Valerious bloodline in defeating Count Dracula . Anna Valerious reveals that Dracula has formed an unholy alliance with Dr. Frankenstein's monster and is hell-bent on exacting a centuries-old curse on her family. Together Anna and Van Helsing set out to destroy their common enemy, but uncover some unsettling secrets along the way.
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