|Zoey Deutch||Rose Hathaway|
|Lucy Fry||Lissa Dragomir|
|Gabriel Byrne||Victor Dashkov|
|Sarah Hyland||Natalie Dashkov|
|Joely Richardson||Queen Tatiana|
|Olga Kurylenko||Headmistress Ellen Kirova|
|Claire Foy||Ms. Karp|
Teenager Rose Hathaway is a Dhampir -- a human/vampire hybrid. Her best friend is Lissa Dragomir, a princess of the Moroi -- mortal, peaceful vampires. Both teens attend St. Vladamir's Academy, a secret haven for those like them. Rose trains with a handsome mentor to guarantee her place as Lissa's guardian -- although she may have to sacrifice everything to protect Lissa from enemies both within St. Vladamir's walls and outside them.