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| Helen Hunt | Dr. JoAnne 'Jo' Thornton-Harding |
| Bill Paxton | William Harding |
| Cary Elwes | Dr. Jonas Miller |
| Jami Gertz | Dr. Melissa Reeves |
| Lois Smith | Meg Greene |
| Alan Ruck | Robert 'Rabbit' Nurick |
| Philip Seymour Hoffman | Dustin Davis |
| Jeremy Davies | Laurence |
| Todd Field | Tim 'Beltzer' Lewis |
| Zach Grenier | Eddie |
| Nicholas Sadler | Kubrick |
| Abraham Benrubi | Bubba |
| Jake Busey | Mobile Lab Technician |
| Scott Thomson | Jason 'Preacher' Rowe |
Storm-chasers finalizing their divorce try to place equipment inside a tornado on the Oklahoma plains.
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