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| David Duchovny | Tom |
| Julianne Moore | Rebecca |
| Billy Crudup | Tobey |
| Maggie Gyllenhaal | Elaine |
| Eva Mendes | Faith |
| Ellen Barkin | Norah |
| Garry Shandling | Dr. Beekman |
| James LeGros | Dante |
| Justin Bartha | Jasper |
| Todd Hofacker | Nigel |
| Dagmara Dominczyk | Pamela |
| Bob Balaban | Tobey's Therapist |
Two New York couples try to navigate through the ever-present pitfalls of love and marriage. A successful actress, her househusband, her ne-er-do-well brother and his girlfriend cope with work demands and infidelity as they search for real love and easy parking.
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