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| Christian Slater | Clarence Worley |
| Patricia Arquette | Alabama Whitman |
| Dennis Hopper | Clifford Worley |
| Val Kilmer | Mentor (Elvis) |
| Gary Oldman | Drexl Spivey |
| Brad Pitt | Floyd |
| Christopher Walken | Vincenzo Coccotti |
| Bronson Pinchot | Elliot Blitzer |
| Michael Rapaport | Dick Ritchie |
| Saul Rubinek | Lee Donowitz |
| Chris Penn | Nicky Dimes |
| Tom Sizemore | Cody Nicholson |
| Samuel L. Jackson | Big Don |
A Detroit comic-book store clerk and his floozy wife flee to Hollywood with a suitcase full of mob cocaine.
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