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| Ewan McGregor | Mark "Rent-boy" Renton |
| Ewen Bremner | Daniel "Spud" Murphy |
| Jonny Lee Miller | Simon David "Sick Boy" Williamson |
| Kevin McKidd | Tommy MacKenzie |
| Robert Carlyle | Francis (Franco) Begbie |
| Kelly Macdonald | Diane |
| Peter Mullan | Swanney |
| James Cosmo | Mr. Renton |
| Eileen Nicholas | Mrs. Renton |
| Susan Vidler | Mrs. Renton |
| Pauline Lynch | Lizzy |
| Shirley Henderson | Gail |
| Stuart McQuarrie | Gavin/US Tourist |
| Irvine Welsh | Mikey Forrester |
| Dale Winton | Game Show Host |
| Keith Allen | Dealer |
| Ann-Louise Ross | Gail's Mother |
| Billy Riddoch | Gail's Father |
| Fiona Bell | Diane's Mother |
| Vincent Friel | Diane's Father |
| Hugh Ross | Man |
| Victor Eadie | Man |
| Kate Donnelly | Woman |
| Finlay Welsh | Sheriff |
| Eddie Nestor | Estate Agent |
Heroin addict Mark Renton stumbles through bad ideas and sobriety attempts with his unreliable friends -- Sick Boy, Begbie, Spud and Tommy . He also has an underage girlfriend, Diane, along for the ride. After cleaning up and moving from Edinburgh to London, Mark finds he can't escape the life he left behind when Begbie shows up at his front door on the lam, and a scheming Sick Boy follows.
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