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| Charlton Heston | Ramon Miguel ``Mike'' Vargas |
| Orson Welles | Police Captain Hank Quinlan |
| Janet Leigh | Susan ``Susie'' Vargas |
| Joseph Calleia | Police Sergeant Pete Menzies |
| Akim Tamiroff | Uncle Joe Grandi |
| Valentin de Vargas | Pancho |
| Ray Collins | District Attorney Adair |
| Dennis Weaver | Mirador Motel Night Manager |
| Joanna Moore | Marcia Linnekar |
| Mort Mills | Al Schwartz, District Attorney's Assistant |
| Marlene Dietrich | Tanya |
| Victor Millan | Manelo Sanchez |
| Lalo Rios | Risto, Grandi's nephew |
| Michael Sargent | Pretty Boy |
| Mercedes McCambridge | Gang leader (uncredited) |
| Joseph Cotten | Coroner (uncredited) |
| Zsa Zsa Gabor | Strip-club owner |
| Phil Harvey | Blaine |
| Joi Lansing | Zita |
| Harry Shannon | Chief Gould |
| Keenan Wynn | Bit part (uncredited) |
When a car bomb explodes on the American side of the U.S./Mexico border, Mexican drug enforcement agent Miguel Vargas begins his investigation, along with American police captain Hank Quinlan . When Vargas begins to suspect that Quinlan and his shady partner, Menzies, are planting evidence to frame an innocent man, his investigations into their possible corruption quickly put himself and his new bride, Susie, in jeopardy.
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