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| Xander Berkeley | Evan Watz |
| Golden Brooks | Onyx Richardson |
| Saffron Burrows | Emma |
| Viveka Davis | Victoria Cohen |
| Richard Edson | Lester Moore |
| Aimee Graham | Sikh Nurse |
| Salma Hayek | Rose |
| Glenne Headly | Therapist |
| Andrew Heckler | Auditioning Actor |
| Holly Hunter | Executive |
| Danny Huston | Randy |
| Daphna Kastner | Auditioning Actress |
| Patrick Kearney | Drug House Owner |
| Elizabeth Low | Penny, Evan's Assistant |
| Kyle MacLachlan | Bunny Drysdale |
| Mia Maestro | Ana Pauls |
| Leslie Mann | Cherine |
| Suzy Nakamura | Connie Ling |
| Alessandro Nivola | Joey Z, Ana's Assistant |
| Zuleikha Robinson | Lester Moore's Assistant |
| Julian Sands | Quentin, the Masseur |
| Stellan Skarsgard | Alex Green |
| Jeanne Tripplehorn | Lauren Hathaway |
| Steven Weber | Darren Fetzer |
A production company begins casting for its next feature, and an up-and-coming actress named Rose tries to manipulate her filmmaker boyfriend, Alex, into giving her a screen test. Alex's wife, Emma, knows about the affair and is considering divorce, while Rose's girlfriend secretly spies on her and attempts to sabotage the relationship. The four storylines in the film were each shot in one take and are shown simultaneously, each taking up a quarter of the screen.
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