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| Xander Berkeley | Evan Watz |
| Golden Brooks | Onyx Richardson |
| Saffron Burrows | Emma |
| Viveka Davis | Victoria Cohen |
| Richard Edson | Lester Moore |
| Aimee Graham | Sikh Nurse |
| Salma Hayek | Rose |
| Glenne Headly | Therapist |
| Andrew Heckler | Auditioning Actor |
| Holly Hunter | Executive |
| Danny Huston | Randy |
| Daphna Kastner | Auditioning Actress |
| Patrick Kearney | Drug House Owner |
| Elizabeth Low | Penny, Evan's Assistant |
| Kyle MacLachlan | Bunny Drysdale |
| Mia Maestro | Ana Pauls |
| Leslie Mann | Cherine |
| Suzy Nakamura | Connie Ling |
| Alessandro Nivola | Joey Z, Ana's Assistant |
| Zuleikha Robinson | Lester Moore's Assistant |
| Julian Sands | Quentin, the Masseur |
| Stellan Skarsgard | Alex Green |
| Jeanne Tripplehorn | Lauren Hathaway |
| Steven Weber | Darren Fetzer |
Four simultaneous, improvised stories center around a movie producer, his wife, an aspiring actress and murder.
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