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| Meg Ryan | Mary Haines |
| Annette Bening | Sylvie Fowler |
| Eva Mendes | Crystal Allen |
| Debra Messing | Edie Cohen |
| Jada Pinkett Smith | Alex Fisher |
| Carrie Fisher | Bailey Smith |
| Cloris Leachman | Maggie |
| Debi Mazar | Tanya |
| Bette Midler | Leah Miller |
| Candice Bergen | Catherine Frazier |
| Tilly Scott Pedersen | Uta |
| India Ennenga | Molly Haines |
| Lynn Whitfield | Glenda Hill |
| Joanna Gleason | Barbara |
| Ana Gasteyer | Pat |
| Jill Flint | Annie |
Clothing designer Mary Haines appears to have it all: a beautiful home in Connecticut, a successful husband, a lovely daughter, and the support of a close circle of friends -- led by magazine editor Sylvie Fowler . When Mary learns her husband is cheating, her pals rally around her. But his infidelity does not compare to the betrayal Mary feels when Sylvie spills the beans about the affair to a gossip columnist she wants to hire for her magazine.
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