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| Basil Rathbone | Sherlock Holmes |
| Nigel Bruce | Doctor John Watson |
| Hillary Brooke | Lydia |
| Henry Daniell | Professor James Moriarty |
| Paul Cavanagh | Sir George Fenwick |
| Matthew Boulton | Inspector Gregson |
| Eve Amber | Maude |
When a number of attractive women are found dead and with fingers missing, Sherlock Holmes and Dr. Watson investigate. Though evidence points to a psychotic killer, Holmes begins to believe that there's more to the case than initially meets the eye, a notion that leads him to uncover the involvement of his archenemy, Professor Moriarty . Who is working with Moriarty on such a dastardly plot and what are their motives?
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