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| Kiefer Sutherland | Samson |
| Eddie Izzard | Nigel |
| James Belushi | Benny |
| Janeane Garofalo | Bridget |
| Jonathan Kimmel | Scab |
| William Shatner | Kazar |
| Clinton Leupp | Mama Hippo |
| Joseph Siravo | Carmine |
| Bob Joles | Cloak |
| Dominic Scott Kay | Young Samson |
| Chris Edgerly | Camo |
| Greg Berg | Vulture |
| Don Cherry | Penguin MC |
| Richard Kind | Larry |
| Greg Cipes | Ryan |
| Colin Hay | Fergus Flamingo |
An adolescent lion who was raised in captivity finds himself accidentally plucked from the New York Zoo and deposited in Africa. Meanwhile, the friends he left behind at the zoo must put aside their differences to help bring him home safely.
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