| Katherine Heigl | Abby Richter |
| Gerard Butler | Mike Chadway |
| Eric Winter | Colin |
| John Michael Higgins | Larry |
| Bree Turner | Joy |
| Nick Searcy | Stuart |
| Kevin Connolly | Jim |
| Cheryl Hines | Georgia |
| Bonnie Somerville | Elizabeth |
| Yvette Nicole Brown | Dori |
| Nate Corddry | Josh |
| Noah Matthews | Jonah |
| Jesse D. Goins | Cliff |
Abby Richter is a lovelorn TV producer who, despite a long and arduous search for the perfect mate, is hopelessly single. The battle of the sexes heats up when her employers team her up with Mike Chadway, an opinionated TV celebrity who plans to put Abby through the wringer to prove his own theories about what makes men and women tick.
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