|Gabriel Macht||Denny Colt/The Spirit|
|Samuel L. Jackson||The Octopus|
|Eva Mendes||Sand Saref|
|Paz Vega||Plaster of Paris|
|Scarlett Johansson||Silken Floss|
|Johnny Simmons||Young Spirit|
Apparently murdered cop Denny Colt returns as the Spirit, dedicated to protecting Central City from crime. His archenemy, the Octopus, is a ruthless killer who will destroy the Spirit's well-loved city to find the secret of immortality. As the Spirit pursues his quarry, he meets many beautiful women who would be happy to either kiss or kill him.