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| Dorothy McGuire | Helen Capel |
| George Brent | Professor Warren |
| Forrest Tucker | |
| Ethel Barrymore | Mrs. Warren |
| Kent Smith | Dr. Parry |
| Rhonda Fleming | Blanche |
| Gordon Oliver | Steve Warren |
| Elsa Lanchester | Mrs. Oates |
| James Bell | Constable |
| Charles Wagenheim | Desk Clerk |
| Ellen Corby | Neighbor |
| Richard Tyler | Freddy |
| Erville Alderson | Dr. Harvey |
| Sara Allgood | Nurse Barker |
| Rhys Williams | Mr. Oates |
A young mute woman who is working in a New England mansion as a domestic is terrorized by a maniac who is killing off people with disabilities. After being warned of the danger to her personal safety she makes plans to leave the dark old house, but it is too late. The maniac is in the house, and she is his prey.
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