| Amber Tamblyn | Tabitha "Tibby" Tomko-Rollins |
| Alexis Bledel | Lena Kaligaris |
| America Ferrera | Carmen Lowell |
| Blake Lively | Bridget |
| Jenna Boyd | Bailey Graffman |
| Bradley Whitford | Al |
| Nancy Travis | Lydia Rodman |
| Rachel Ticotin | Carmen's Mother |
| Mike Vogel | Eric Richman |
| Michael Rady | Kostas |
| Leonardo Nam | Brian |
| Maria Konstandarou | Yia Yia |
| George Touliatos | Papou |
| Kyle Schmid | Paul Rodman |
| Emily Tennant | Krista Rodman |
| Jacqueline Stewart | Lena's Mother |
| Sarah-Jane Redmond | Tibby's Mother |
| Ernie Lively | Bridget's Father |
| Kendall Cross | Bridget's Mother |
| Kristie Marsden | Olivia |
| Patricia Mayan Salazar | Camp Director Donna |
| Patricia Drake | Coach Karen |
| Valerie Tian | Interview Girl #1 |
| Georgia Craig | Saleslady |
| Erica Hubbard | Diana |
More The Sisterhood of the Traveling Pants Pictures
Bridget, Carmen, Lena and Tibby are best friends living in Maryland. After many summers together, the four are finally going their separate ways for a few months: while Bridget heads to Mexico, and Lena visits family in Greece, Carmen and Tibby stay closer to home. No matter where they are, they are connected by a pair of jeans that they take turns sharing -- pants that fit all four girls and exemplify their tight bond.
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