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| Robert Downey Jr. | Dan Dark |
| Robin Wright Penn | Nicola/Nina/Blonde |
| Mel Gibson | Dr. Gibbon |
| Jeremy Northam | Mark Binney |
| Katie Holmes | Nurse Mills |
| Adrien Brody | First Hood |
| Jon Polito | Second Hood |
| Carla Gugino | Betty Dark/Hooker |
| Saul Rubinek | Skin Specialist |
| Alfre Woodard | Chief of Staff |
| Amy Aquino | Nurse Nozhki |
| David Dorfman | Young Dan Dark |
| Eddie Jones | Moonglow Bartender |
| Lily Knight | Woman Physiotherapist |
| Clyde Kusatsu | Visiting Japanese Doctor |
| Earl C. Poitier | Orderly |
| Don Fischer | Intern |
| Andy Umberger | Mr. Dark |
Hospitalized for a severe skin disease, a bitter writer imagines he is the gumshoe from his novel.
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