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| Tim Allen | Dave Douglas |
| Robert Downey Jr. | Marcus Kozak |
| Danny Glover | D.A. Ken Hollister |
| Kristin Davis | Rebecca Douglas |
| Craig Kilborn | Neighbor |
| Spencer Breslin | Joe Douglas |
| Zena Grey | Carly Douglas |
| Jane Curtin | Judge |
| Shawn Pyfrom | Trey |
| Jeanette Brox | Janey |
Deputy District Attorney Dave Douglas is a workaholic and frequently puts his job before his family. After taking on a case involving an animal laboratory, he becomes infected with a top-secret serum that transforms him into a dog. Life as a canine gives Dave new perspective on the importance of family, but before he can make things right with his wife and kids, he must sniff out the villains responsible for the serum.
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