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| Tom Conway | Dr. Louis Judd |
| Kim Hunter | Mary Gibson |
| Jean Brooks | Jacqueline Gibson |
| Hugh Beaumont | Gregory Ward |
| Erford Gage | Jason Hoag |
| Isabel Jewell | Frances Fallon |
| Marguerita Sylva | Mrs. Bella Romari |
| Evelyn Brent | Natalie Cortez |
| Mary Newton | Esther Redi |
| Jameson Shade | Swenson (uncredited) |
| Eve March | Mildred Gilchrist |
| Ottola Nesmith | Mrs. Lowood |
| Edythe Elliott | Mrs. Swift (uncredited) |
| Milton Kibbee | Joseph (uncredited) |
| Marianne Mosner | Miss Rowan (uncredited) |
| Barbara Hale | Subway Passenger (uncredited) |
| William Halligan | Paul Radeaux |
| Dewey Robinson | Subway Conductor (uncredited) |
After young Mary Gibson discovers that her older sister Jacqueline has disappeared, she leaves her boarding school and heads to New York City to track down her sibling. Arriving at Jacqueline's apartment, Mary finds ominous signs of trouble, with her sister nowhere in sight. Aided by psychiatrist Dr. Louis Judd and others, Mary gets drawn deeper into the mystery, and evidence begins to point to the involvement of a sinister cult.
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