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| Nicol Williamson | Sherlock Holmes |
| Alan Arkin | Dr. Sigmund Freud |
| Robert Duvall | Dr. John H. Watson/Narrator |
| Vanessa Redgrave | Lola Deveraux |
| Laurence Olivier | Professor James Moriarty |
| Joel Grey | Lowenstein |
| Samantha Eggar | Mary Morstan Watson |
| Jeremy Kemp | Baron Karl von Leinsdorf |
| Charles Gray | Mycroft Holmes |
| Georgia Brown | Mrs. Freud |
| Anna Quayle | Freda |
| Jill Townsend | Mrs. Holmes |
| John Bird | Berger |
| Alison Leggatt | Mrs. Hudson |
In this bizarre twist on Sir Arthur Conan Doyle's classic detective tales, Sherlock Holmes finds himself experiencing vivid hallucinations resulting from his cocaine addiction. Concerned about his friend's personal and professional welfare, the loyal Dr. Watson contracts Sigmund Freud to analyze Holmes' drug-addled mind, while the legendary sleuth also investigates the mysterious kidnapping of Lola Devereaux .
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