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| Elizabeth Hartman | Mrs. Brisby |
| Derek Jacobi | Nicodemus |
| Dom DeLuise | Jeremy |
| Shannen Doherty | Teresa |
| Edie McClurg | Miss Right |
| John Carradine | Great Owl |
| Wil Wheaton | Martin |
| Peter Strauss | Justin |
| Norbert Auerbach | Councilman 1 |
| Hermione Baddeley | Auntie Shrew |
| Lucille Bliss | Mrs. Fitzgibbons |
| Charles Champlin | Councilman 3 |
| Ian Fried | Timothy |
| Tom Hatten | Farmer Fitzgibbons |
| Jodi Hicks | Cynthia |
| Dick Kleiner | Councilman 2 |
| Joshua Lawrence | Billy Fitzgibbons |
| Arthur Malet | Mr. Ages |
| Aldo Ray | Sullivan |
| Paul Shenar | Jenner |
A society of genetically altered rats comes to the aid of a mouse whose family is threatened by civilization.
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