| Queen Latifah | August Boatwright |
| Dakota Fanning | Lily Owens |
| Jennifer Hudson | Rosaleen |
| Alicia Keys | June Boatwright |
| Sophie Okonedo | May Boatwright |
| Nate Parker | Neil |
| Tristan Wilds | Zachary Taylor |
| Hilarie Burton | Deborah Owens |
| Paul Bettany | T. Ray Owens |
Haunted by memories of her late mother, 14-year-old Lily Owens runs away with her friend and caregiver Rosaleen to the South Carolina town that holds the key to her mother's past. There, Lily meets the Boatwright sisters, who take her in and teach her about beekeeping, honey, and the Black Madonna.
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