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| Sean Connery | John Patrick Mason |
| Nicolas Cage | Dr. Stanley Goodspeed |
| Ed Harris | General Francis X. Hummel |
| Michael Biehn | Commander Anderson |
| William Forsythe | Special Agent Ernest Paxton |
| David Morse | Major Tom Baxter |
| John Spencer | FBI Director James Womack |
| John C. McGinley | Captain Hendrix |
| Tony Todd | Captain Darrow |
| Bokeem Woodbine | Sergeant Crisp |
| Danny Nucci | Lieutenant Shephard |
| Claire Forlani | Jade Angelou |
| Vanessa Marcil | Carla Pestalozzi |
| Greg Sporleder | Captain Frye |
A one-time escaped convict leads Navy SEALs onto Alcatraz to thwart a renegade colonel's rebels who threaten the area with warheads.
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