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| Thomas Jane | Frank Castle/The Punisher |
| John Travolta | Howard Saint |
| Will Patton | Quentin Glass |
| Roy Scheider | Frank Castle Sr. |
| Laura Harring | Livia Saint |
| Ben Foster | Dave |
| Samantha Mathis | Maria Castle |
| James Carpinello | John Saint/Bobby Saint |
| Russell Andrews | FBI Agent Jimmy Weeks |
| Eddie Jemison | Micky Duka |
| John Pinette | Mr. Bumpo |
| Rebecca Romijn-Stamos | Joan |
| Mark Collie | Harry Heck |
| Eduardo Yáñez | Mike Toro |
| Omar Avila | Joe Toro |
| Kevin Nash | The Russian |
| Marcus Johns | Will Castle |
An FBI agent becomes a gun-toting vigilante after a crooked businessman orders hit men to murder his family.
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