| Robert Stephens | Sherlock Holmes |
| Colin Blakely | Dr.John H. Watson |
| Genevieve Page | Ilse von Hoffmanstal, aka Gabrielle Valladon |
| Irene Handl | Mrs. Hudson |
| Stanley Holloway | Gravedigger |
| Christopher Lee | Mycroft Holmes |
| Clive Revill | Nikolai Rogozhin |
| Tamara Toumanova | Madame Petrova |
| George Benson | Insp. Lestrade (scenes deleted) |
| Catherine Lacey | Woman in Wheelchair |
| Peter Madden | Von Tirpitz |
| Robert Cawdron | Hotel manager |
| Michael Elwyn | Cassidy (scenes deleted) |
A bored Sherlock Holmes meets Madame Petrova, a famed ballerina, who tries to seduce him, hoping that their child will have her body and his brains. He manages to extract himself from her grasp, using Dr. Watson as a decoy. Then he and the doctor head for Loch Ness in search of the missing husband of Gabrielle Valladon . While there, they meet Sherlock's brother, Mycroft, who aids them in solving the mystery.
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