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| George Clooney | Captain Billy Tyne |
| Mark Wahlberg | Bobby Shatford |
| John C. Reilly | |
| Diane Lane | Christina "Chris" Cotter |
| William Fichtner | David "Sully" Sullivan |
| John Hawkes | Mike "Bugsy" Moran |
| Allen Payne | Alfred Pierre |
| Mary Elizabeth Mastrantonio | Linda Greenlaw |
| Karen Allen | Melissa Brown |
| Cherry Jones | Edie Bailey |
| Bob Gunton | Alexander McAnally III |
| Christopher McDonald | Todd Gross |
| Dash Mihok | Sgt. Jeremy Mitchell |
| Josh Hopkins | Capt. Daryl Ennis |
| Michael Ironside | Bob Brown |
| Rusty Schwimmer | Irene |
| Janet Wright | Ethel Shatford |
At sea in October 1991, the crewmen of the Andrea Gail encounter a storm with hurricane-strength winds and 100-foot waves.
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