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| Liev Schreiber | Robert Thorn |
| Julia Stiles | Katherine Thorn |
| Mia Farrow | Mrs. Baylock |
| David Thewlis | Jennings |
| Pete Postlethwaite | Father Brennan |
| Seamus Davey-Fitzpatrick | Damien |
| Michael Gambon | Bugenhagen |
| Nikki Amuka-Bird | Dr. Becker |
| Marshall Cupp | Steven Haines |
| Reggie Austin | Tom Portman |
A new age of evil threatens to arise when an American diplomat and his wife learn that the child they adopted may be the son of Satan. Mystical signs point to the Antichrist's coming battle for dominion over heaven and Earth.
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