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| Jack Lemmon | Felix Ungar |
| Walter Matthau | Oscar Madision |
| Christine Baranski | Thelma |
| Barnard Hughes | Beaumont |
| Jonathan Silverman | Brucey Madison |
| Jean Smart | Holly |
| Lisa Waltz | Hannah Ungar |
| Mary Beth Peil | |
| Doris Belack | Blanche Madison Povich |
| Ellen Geer | Frances Ungar Melnick |
| Jay O. Sanders | Leroy |
| Rex Linn | Jay Jay |
| Peggy Miley | Millie, the Nosher |
| Alice Ghostley | Esther, the Whiner |
| Mary Fogerty | Flossie, the Grouch |
| Rebecca Schull | Wanda, the Vixen |
| Florence Stanley | Hattie |
| Lou Cutell | Abe |
A slob and a neat freak, former roommates, meet again years later for their children's wedding.
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