|Leslie Nielsen||Lt. Frank Drebin|
|George Kennedy||Captain Ed Hocken|
|Priscilla Presley||Jane Spencer|
|Ricardo Montalban||Vincent Ludwig|
|O.J. Simpson||Det. Nordberg|
|Nancy Marchand||Mayor Barkley|
|Susan Beaubian||Mrs. Nordberg|
Frank Drebin, a rather clueless police detective, tries to foil a plot to turn innocent people into assassins through mind control. After his partner, Norberg, is shot, Frank sets out to find the culprit, leading him to business tycoon Vincent Ludwig . However, Frank has no evidence until he meets Jane Spencer, Ludwig's assistant. She knows nothing about Ludwig's devious plans, but falls for Frank and agrees to help him.