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| Leslie Nielsen | Lt. Frank Drebin |
| George Kennedy | Captain Ed Hocken |
| Priscilla Presley | Jane Spencer |
| Ricardo Montalban | Vincent Ludwig |
| O.J. Simpson | Det. Nordberg |
| Nancy Marchand | Mayor Barkley |
Frank Drebin, a rather clueless police detective, tries to foil a plot to turn innocent people into assassins through mind control. After his partner, Norberg, is shot, Frank sets out to find the culprit, leading him to business tycoon Vincent Ludwig . However, Frank has no evidence until he meets Jane Spencer, Ludwig's assistant. She knows nothing about Ludwig's devious plans, but falls for Frank and agrees to help him.
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