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| Anne Bancroft | Annie Sullivan |
| Patty Duke | Helen Keller |
| Victor Jory | Captain Arthur Keller |
| Inga Swenson | Kate Keller |
| Andrew Prine | James Keller |
| Kathleen Comegys | Aunt Ev |
| Beah Richards | Viney, Keller Maid (uncredited) |
| Jack Hollander | Mr. Anagnos of Perkins School in Boston (uncredited) |
Blind and deaf after suffering a terrible fever as a baby, young Helen Keller has spent years unable to communicate, leaving her frustrated and occasionally violent. As a last chance before she is institutionalized, her parents contact a school for the blind, which sends half-blind Annie Sullivan to teach Helen. Helen is initially resistant, but Annie gradually forms a bond with her and shows Helen ways of reaching others.
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