|Louis Calhern||Oliver Wendell Holmes|
|Ann Harding||Fanny Bowditch Holmes|
|Eduard Franz||Judge Louis Brandeis|
Supreme Court Justice Oliver Wendell Holmes spends his leisure time at his home, where he entertains guests with the assistance of his loving wife, Fanny . His most trusted friend is Judge Louis Brandeis, with whom he spends hours debating the law. When Fanny dies, Holmes is heartbroken and aimless, but he finds direction again by dedicating himself to his court duties and teaching the Harvard law clerks who come to work for him.