| Jennifer Aniston | Annie Hughes |
| Eli Marienthal | Hogarth Hughes |
| Harry Connick Jr. | Dean McCoppin |
| Vin Diesel | The Iron Giant |
| Christopher McDonald | Kent Mansley (as Christopher MacDonald) |
| James Gammon | Marv Loach/Floyd Turbeaux/General Sudokoff |
| Cloris Leachman | Mrs. Lynley Tensedge |
| John Mahoney | General Rogard |
| M. Emmet Walsh | Earl Stutz |
A malevolent government agent threatens to destroy the friendship between a boy and a huge alien robot.
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