| Claude Rains | Jack Griffin |
| Gloria Stuart | Flora Cranley |
| Henry Travers | Dr. Cranley |
| William Harrigan | Dr. Arthur Kemp |
| Una O'Connor | Jenny Hall |
| Forrester Harvey | Herbert Hall |
| Holmes Herbert | Chief of Police |
| E.E. Clive | Const. Jaffers |
| Dudley Digges | Chief Detective |
| Harry Stubbs | Inspector Bird |
| Donald Stuart | Inspector Lane |
| Merle Tottenham | Millie |
While researching a new drug, Dr. Jack Griffin stumbles on a potion that can make him invisible. When he reveals his new ability to his old mentor and his fiancée, it's clear that a side effect of the potion is insanity. Jack goes on a violent rampage, and the police struggle to hunt him down, unable to see their target, while his mentor and his former partner desperately try to devise a plan to capture him.
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