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| Al Pacino | Lowell Bergman |
| Russell Crowe | Jeffrey Wigand |
| Christopher Plummer | Mike Wallace |
| Diane Venora | Liane Wigand |
| Philip Baker Hall | Don Hewitt |
| Lindsay Crouse | Sharon Tiller |
| Debi Mazar | Debbie De Luca |
| Stephen Tobolowsky | Eric Kluster |
| Colm Feore | Richard Scruggs |
| Bruce McGill | Ron Motley |
| Gina Gershon | Helen Caperelli |
| Michael Gambon | Thomas Sandefur |
| Rip Torn | John Scanlon |
| Lynne Thigpen | Mrs. Williams |
| Hallie Kate Eisenberg | Barbara Wigand |
| Michael Paul Chan | Norman |
| Linda Hart | Mrs. Wigand |
| Robert Harper | Mark Stern |
| Nestor Serrano | FBI Agent Robertson |
| Pete Hamill | NY Times Reporter |
| Wings Hauser | Tobacco Lawyer |
| Clifford Curtis | Sheikh Fadlallah |
| Renee Olstead | Deborah Wigand |
| Michael Moore | Michael Moore |
After seeking the expertise of former ''Big Tobacco'' executive Jeffrey Wigand, seasoned TV producer Lowell Bergman suspects a story lies behind Wigand's reluctance to speak. As Bergman persuades Wigand to share his knowledge of industry secrets, the two must contend with the courts and the corporations that stand between them and exposing the truth. All the while, Wigand must struggle to maintain his family life amidst lawsuits and death threats.
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