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| Anthony Hopkins | Coleman Silk |
| Nicole Kidman | Faunia Farley |
| Ed Harris | Lester Farley |
| Gary Sinise | Nathan Zuckerman |
| Wentworth Miller | Young Coleman Silk |
| Jacinda Barrett | Steena Paulsson |
| Harry J. Lennix | Mr. Silk |
| Clark Gregg | Nelson Primus |
| Anna Deavere Smith | Mrs. Silk |
| Lizan Mitchell | Ernestine |
| Kerry Washington | Ellie |
| Phyllis Newman | Iris Silk |
| Margo Martindale | Psychologist |
| Ron Canada | Herb Keble |
| Mili Avital | Young Iris |
| Danny Blanco Hall | Walter |
| Kristen Blevins | Young Ernestine |
| Anne Dudek | Lisa Silk |
| Mimi Kuzyk | Professor Delphine Roux |
| John Finn | Louie Borero |
A respected professor tries to conceal a long-term secret after inadvertently causing a racial controversy.
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