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| Rob Schneider | Jessica |
| Anna Faris | April |
| Matthew Lawrence | Billy |
| Eric Christian Olsen | Jake |
| Robert Davi | Stan |
| Melora Hardin | Carol |
| Alexandra Holden | Lulu |
| Rachel McAdams | Jessica |
| Maritza Murray | Keecia |
| Fay Hauser | Mrs. Thomas |
| Jodi Long | Keecia's Mom |
| Tia Mowry | Venelia |
| Tamera Mowry | Sissy |
| Lee Garlington | Ms. Marjorie Bernard |
| Angie Stone | Madam Mambuza |
| Matt Weinberg | Booger Spencer |
| Leila Kenzle | Julie, April's Mom |
| Michelle Branch | Instant Tang DJ |
| Michael O'Keefe | Richie Spencer |
| Adam Sandler | Mambuza Bongo Guy (uncredited) |
An ancient curse causes a mean-spirited teenage girl and an incompetent male thief to switch bodies.
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