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| Bradley Cooper | Phil |
| Ed Helms | Stu |
| Zach Galifianakis | Alan |
| Justin Bartha | Doug |
| Heather Graham | Jade |
| Jeffrey Tambor | Sid |
| Sasha Barrese | Tracy |
| Ken Jeong | Mr. Chow |
| Rachael Harris | Melissa |
| Mike Tyson | Himself |
| Mike Epps | Black Doug |
| Jernard Burks | Leonard |
| Rob Riggle | Officer Franklin |
| Cleo King | Officer Garden |
| Bryan Callen | Eddie |
| Matt Walsh | Dr. Valsh |
Two days before his wedding, Doug and three friends drive to Las Vegas for a wild and memorable stag party. In fact, when the three groomsmen wake up the next morning, they can't remember a thing; nor can they find Doug. With little time to spare, the three hazy pals try to re-trace their steps and find Doug so they can get him back to Los Angeles in time to walk down the aisle.
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