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| Amber Tamblyn | Aubrey |
| Sarah Michelle Gellar | Karen |
| Jennifer Beals | Trish |
| Arielle Kebbel | Allison |
| Teresa Palmer | Vanessa |
| Takako Fuji | Kayako |
| Ryo Ishibashi | Det. Nakagawa |
| Misako Uno | Miyuki |
| Edison Chen | Eason |
| Joanna Cassidy | Mrs. Davis |
| Sarah Roemer | Lacey |
| Matthew Knight | Jake |
| Ohga Tanaka | Toshio |
| Christopher Cousins | Bill |
| Paul Jarrett | John Fleming |
| Jenna Dewan | Sally |
A young woman encounters a terrible curse while searching for her missing sister in Tokyo. The evil imprecation fills its victims with murderous rage, but it also brings together the diverse group to unlock its secret and save their lives.
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