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| Harrison Ford | Dr. Richard Kimble |
| Tommy Lee Jones | Samuel Gerard |
| Sela Ward | Helen Kimble |
| Julianne Moore | Dr. Anne Eastman |
| Joe Pantoliano | Cosmo Renfro |
| Jeroen Krabbe | Dr. Charles Nichols |
| Andreas Katsulas | Sykes |
| Daniel Roebuck | Biggs |
| L. Scott Caldwell | Poole |
Wrongfully accused of murdering his wife, Richard Kimble escapes from the law in an attempt to find her killer and clear his name. Pursuing him is a team of U.S. marshals led by Deputy Samuel Gerard, a determined detective who will not rest until Richard is captured. As Richard leads the team through a series of intricate chases, he discovers the secrets behind his wife's death and struggles to expose the killer before it is too late.
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